Therapeutic Expertise

Image Core Lab is your trusted imaging partner for global clinical trials and radiology AI development. Our board-certified radiologists deliver protocol-driven reads guided by validated scoring systems across all major therapeutic areas. 

Oncology Imaging

Oncology trials account for a majority of our clinical imaging work, making it the cornerstone of Image Core Lab’s therapeutic expertise. We deliver high-quality imaging reads that meet regulatory standards globally.

Key Focus Areas

  • Solid Tumors: Breast, Colorectal, Ovarian, Prostate, Pancreatic, Lung, Bladder, Kidney, Stomach, Skin, Brain
  • Hematologic Cancers: Lymphomas, Myeloma, Leukemia
We support imaging endpoints across a wide spectrum of cancer types, adapting to trial needs through both general and subspecialty radiologists. Our radiologists are extensively trained in the criteria to maintain scoring consistency in blinded, multicenter environments. We objectively measure changes and treatment responses adding a layer of precision beyond conventional size-based criteria. These quantitative endpoints enhance confidence in assessing disease progression and therapeutic effects.
Focus Area RECIST 1.1 iRECIST irRC LUGANO IMWG RANO iwCLL
Bladder ✅ ✅ ✅ – – – –
Breast ✅ ✅ ✅ – – – –
Colorectal ✅ ✅ ✅ – – – –
Glioma – – – – – ✅ –
Kidney ✅ ✅ ✅ – – – –
Leukemia – – – – – – ✅
Lung ✅ ✅ ✅ – – – –
Lymphomas – – – ✅ – – –
Melanoma ✅ ✅ ✅ – – – –
Myeloma – – – – ✅ – –
Ovarian ✅ ✅ ✅ – – – –
Pancreatic ✅ ✅ ✅ – – – –
Prostate ✅ ✅ ✅ – – – –
Stomach ✅ ✅ ✅ – – – –

Musculoskeletal Imaging

Musculoskeletal (MSK) imaging is a cornerstone in clinical trials assessing biologics, orthopedic implants, and emerging robotic-assisted surgical procedures. Our expertise combines subspecialty radiology with standardized scoring systems such as RAMRIS and Kellgren-Lawrence to deliver precise reads critical for MSK therapeutic development and device validation. Key Focus Areas
  • Rheumatoid Arthritis
  • Osteoporosis
  • Osteoarthritis
  • Degenerative Disc Disease
Our MSK radiologists understand the nuances of inflammatory, degenerative, and traumatic musculoskeletal conditions, applying rigorous imaging protocols that align with clinical trial objectives. While clinical trials remain at the core, our MSK expertise extends to orthopedic device validation and radiology AI development.
Focus Area  vdH-mTSS RAMRIS Fracture Healing Metrics Kellgren-Lawrence Score
Degenerative Disc Disease – – ✅ –
Osteoarthritis – – – ✅
Osteoporosis – – ✅ –
Rheumatoid Arthritis ✅ ✅ – –

Gastrointestinal (GI) Imaging

Gastrointestinal imaging plays a crucial role in evaluating mucosal healing, treatment efficacy, and long-term disease control in IBD trials. Our radiologists ensure accurate evaluations across study arms and geographies. Key Focus Areas
  • Inflammatory Bowel Disease (IBD)
  • Crohn’s Disease
  • Ulcerative Colitis
These chronic and often debilitating conditions demand precise imaging endpoints. We provide expert, protocol-driven reads across GI indications by applying scoring systems. With experience in ulcerative colitis studies, we provide clinical-grade interpretations aligned with regulatory endpoints.
Focus Area Mayo Endoscopic Score Endoscopic Indexes
Crohn’s Disease  – ✅ 
Inflammatory Bowel Disease  ✅  ✅ 
Ulcerative Colitis ✅ ✅ 

Cardiovascular Imaging 

Cardiovascular imaging plays a pivotal role in evaluating structural and functional cardiac abnormalities in clinical trials. At Image Core Lab, we support trials across a spectrum of cardiovascular conditions delivering precise, reproducible measurements essential for endpoint validation and regulatory submission. Key Focus Areas
  • Cardiomyopathies
  • Congenital Heart Defects
  • Coronary Artery Disease
  • Heart Failure
  • Valvular Heart Disease
Our subspecialist radiologists support the various imaging modalities and implement standardized imaging criteria. Each read is aligned with trial-specific protocols and regulatory expectations, with centralized interpretation minimizing inter-reader variability across global multicenter studies.
Focus Area LVEF Calcium Scoring SYNTAX Score Gensini Score Duke CAD Index CAD-RADS 2.0 MRI Stress Perfusion
Cardiomyo-pathies ✅ – – – – – ✅
Congenital Heart Defects ✅ – – – – – ✅
Coronary Artery Disease (CAD) ✅ ✅ ✅ ✅ ✅ ✅ ✅
Heart Failure ✅ – – – ✅ – ✅
Valvular Heart Disease ✅ ✅ – – – – ✅

Neuroimaging 

Clinical trials targeting CNS disorders often face high failure rates due to variability in reads, and lack of standardized criteria. We help mitigate these risks by offering protocol-driven reads tailored to therapeutic-specific endpoints. Key Focus Areas
  • Stroke
  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Epilepsy
  • Brain Injury
  • Multiple Sclerosis
Our board-certified neuroradiologists specialize in interpreting scans for a wide spectrum of central nervous system conditions. We support the development and validation of neuro-focused radiology AI solutions.
Focus Area McDonald Criteria Volumetric Assessment
Alzheimer’s Disease – ✅
Stroke – ✅ 
Parkinson’s Disease – ✅ 
Epilepsy – ✅ 
Brain Injury (TBI) – ✅ 
Multiple Sclerosis ✅ ✅

Get in touch with us

Feel free to contact any time by filling the form given below. Our customer support team or sales team will get in touch with you at the earliest

Frequently Asked Questions

What is therapeutic imaging in clinical trials?

Therapeutic imaging involves using medical imaging to evaluate disease progression, treatment response, and clinical endpoints within a specific therapeutic area such as oncology, MSK, or CNS.

How does Image Core Lab ensure consistency in imaging reads?
We follow response criteria (e.g., RECIST, RAMRIS, McDonald) and standardized imaging protocols, with all reads performed by subspecialty radiologists and audited for quality.
What therapeutic areas do you cover?
We offer imaging services across oncology, musculoskeletal, gastrointestinal, cardiovascular, and central nervous system trials, with AI and SaMD validation support in each.
Can you support AI algorithm development for radiology?
Yes, Image Core Lab supports AI algorithm development for radiology. We provide expert-annotated datasets, image review services, and clinical validation support for SaMD and AI developers across multiple therapeutic domains.
Is your imaging workflow compliant with regulatory standards?
Yes. Our workflows comply with ICH-GCP, FDA 21 CFR Part 11, and HIPAA requirements for data integrity, patient privacy, and regulatory readiness.ple therapeutic domains.